Andrographis paniculata as Promising Novel Protective Therapy of Oxidative Stress in Indomethacin-Induced Gastric Ulcer in Rats

This research investigated the effect of Andrographis paniculata (AP) on oxidative stress following indomethacin-induced gastric ulcer in rats. A total 20 male albino Wistar rats (150-180g) used for this study were grouped into four (n=5): 1, Negative Control; 2, Positive Control and 3, test group treated with normal chow, 20mg/kg indomethacin, mg/kg indomethacin plus omeprazole at AP 16.7 respectively. After treatment period, estimation parameters was carried out animals. The LD50 aqueous extract 50mg/kg bw. Body weight change significantly reduced compared to all other groups while had increased body change. There a significant increase malondialdehyde (MDA) level untreated groups. two MDA group. decrease levels GPx SOD control. Meanwhile, these Catalase three when control but its From study, has proved protect against implicated pathogenesis ulcer. If result is applicable humans, further use ameliorating debilitating consequences peptic should be encouraged.